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BARDA funds drug development for biothreats, antibiotic resistance

The U.S. Department of Health and Human Services’ Biomedical Advanced Research and Development Authority (BARDA) today awarded a contract to develop an antibiotic that could be used against possible two types of bioterrorism as well as common infections that are becoming resistant to antibiotics.

Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys.

Related Articles Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys. Vaccine. 2010 Aug 19; Authors: Zielinski RJ, Smedley JV, Perera PY, Silvera PM, Waldmann TA, Capala J, Perera LP Despite the eradication  Read More »

Progress toward development of vaccines against melioidosis: A review.

Related Articles Progress toward development of vaccines against melioidosis: A review. Clin Ther. 2010 Aug;32(8):1437-1445 Authors: Sarkar-Tyson M, Titball RW Background: Melioidosis is a serious and often fatal disease that is prevalent in subtropical and tropical climates, primarily in at-risk groups (eg, those with diabetes, alcoholism, or other cause of immunosuppression).  Read More »

Update: RNAi Based Treatments for Ebola

PMO Backbone Structure (Credit: AVI BioPharma)Another RNAi based treatment for Ebola has been developed. Researchers at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) found that >60% of monkeys given a lethal dose of Zaire Ebola virus survived after treatment with AVI-6002, a targeted, positively charged, anti-sense phosphorodiamidate morpholino  Read More »

Evaluation of a biological risk management tool on large western United States dairies.

Related Articles Evaluation of a biological risk management tool on large western United States dairies. J Dairy Sci. 2010 Sep;93(9):4096-4104 Authors: Moore DA, Leach DA, Bickett-Weddle D, Andersen K, Castillo AR, Collar CA, Higginbotham G, Peterson N, Reed B, Hartman ML Critical to changing biosecurity practices on the farm is an  Read More »