The 2001 outbreak of foot and mouth disease (FMD) in the United Kingdom decisively illustrated the devastation that this highly contagious animal disease can cause to a nation’s economy. By the time the disease was eradicated, the United Kingdom had slaughtered more than 4 million animals and sustained losses of $5 billion in the food and agricultural sectors, as well as comparable losses to its tourism industry. Before 2001, the United Kingdom had been FMD-free for almost 34 years. Following the outbreak, the country was generally barred from participating in the international trade of live animals and animal products that could transmit the virus. The United States has adequate processes for obtaining information on foreign FMD outbreaks and providing the Department of Agriculture (USDA) and others with this information, but it lacks adequate processes for sharing this information with the Customs Service. The United States receives information on FMD outbreaks from USDA officials stationed abroad, international agricultural and animal health organizations, and foreign governments. These officials collect a wide array of agricultural and animal health information about the countries and regions in which they are stationed, which ensures that the United States has timely access to information on foreign FMD outbreaks. However, USDA’s processes for disseminating information on foreign FMD outbreaks are uneven. U.S. measures to prevent the introduction of FMD are comparable to those used by other countries and have kept the United States free of the the disease for 75 years. Nevertheless, because of the nature of the disease and the risk inherent in the ever-increasing volume of international travel and trade, U.S. livestock remains vulnerable to the disease. USDA has a two-pronged approach to prevent FMD from reaching U.S. livestock. USDA tries to keep FMD as far as possible from U.S. borders by helping other countries control and eradicate the disease. USDA has developed and implemented specific preventive measures at ports of entry to ensure that international cargo, animals, passengers, and mail do not bring the disease into the United States. In the event of an FMD outbreak, the United States will face several challenges in mounting an effective and quick response, although USDA and many states have developed and tested emergency animal disease response plans.